Bivalent ligands incorporating curcumin and diosgenin as multifunctional compounds against Alzheimer's disease.

Chojnacki JE, Liu K, Saathoff JM, Zhang S.

Bioorg Med Chem, 2015, 23, 7324-31

Curcumin/melatonin hybrid, 5-(4-hydroxy-phenyl)-3-oxo-pentanoic acid [2-(5-methoxy-1H-indol-3-yl)-ethyl]-amide, ameliorates AD-like pathology in the APP/PS1 mouse model

Gerenu G, Liu K, Chojnacki JE, Saathoff JM, Martinez-Martin P, Perry G, Zhu X, Lee HG, Zhang S.

ACS Chem Neurosci, 2015, 6, 1393-9.

Bivalent compound 17MN exerts neuroprotection through interaction at multiple sites in a cellular model of Alzheimer's disease.

Liu K, Chojnacki JE, Wade EE, Saathoff JM, Lesnefsky EJ, Chen Q, Zhang S.

J Alzheimers Dis, 201547, 1021-33.

Pharmacologic inhibition of the NLRP3 inflammasome preserves cardiac function after ischemic and non-ischemic cardiac injury in the mouse

Marchetti C, Toldo S, Chojnacki J, Mezzaroma E, Liu K, Salloum F, Nordio A, Carbone S, Mauro AG, Das A, Zalavadia AA, Halquist MS, Federici M, Van Tassell B, Zhang S, Abbate A.

J Cardiovasc Pharmacol, 201566, 1-8.